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2011”NˆΘ~‚̋ƐΡ
1. H. Hiramatsu, R. Suzuki, S. Yamada, M. Ihira, Y. Isegawa, Y. Kawamura, E. Matsuoka, H. Miura, T. Yoshikawa. Analysis of ganciclovir resistant HHV-6B clinical isolates using quenching probes PCR(QP-PCR) methodology. Antimicrobial Agents and Chemotherapy in press (2015).

2010”NˆΘ‘O‚̋ƐΡ
1. Y. Isegawa, C. Matsumoto, K. Nishinaka, K. Nakano, T. Tanaka, N. Sugimoto, A. Ohshima. PCR with quenching probes enables the rapid detection and identfication of ganciclovir-resistance-causing U69 gene mutations in human herpesvirus 6. Molecular and Cellular Probes 24:167-177, (2010).

2. K. Nakano, K. Nishinaka, T. Tanaka, A. Ohshima, N. Sugimoto, Y. Isegawa. Detection and identification of U69 gene mutations encoded by ganciclovir-resistant human herpesvirus 6 using denaturing high-performance liquid chromatography. Journal of Virological Methods 161:223-230, (2009).

3. R. Sjahril, Y. Isegawa, T. Tanaka, K. Nakano, T. Yoshikawa, Y. Asano, A. Ohshima, K. Yamanishi, N. Sugimoto. Relationship between U83 gene variation in human herpesvirus 6 and secretion of the U83 gene product. Archives of Virology 154:273-283, (2009).

4. Y. Isegawa, J. Hara, K. Amo, Y. Osugi, M. Takemoto, K. Yamanishi, R. Fukunaga, M. Shibata, A. Ohshima, Y. Horiguchi, N. Sugimoto. Human herpesvirus 6 ganciclovir-resistant strain with amino acid substitutions associated with the death of a recipient after an allogeneic stem cell transplant recipient. Journal of Clinical Virology 44:15-19, (2009).

5. Y. Isegawa, Y. Miyamoto, Y. Yasuda, K. Semi, K. Tsujimura, R. Fukunaga, A. Ohshima, Y. Horiguchi, Y. Yonega, and N. Sugimoto. Characterization of human herpesvirus 6 U69 gene product and identification of its nuclear localization signal. Journal of Virology 82:710-718, (2008).

6. W. M. Yeo, Y. Isegawa, and V. T. K. Chow. The U95 protein of human herpesvirus type6B interacts with human GRIM-19: Silencing of U95 expression reduces viral load and abrogates loss of mitochondrial membrane potential. Journal of Virology 82:1011-1020, (2008).

7. Y. Isegawa, J. Katahira, K. Yamanishi, N. Sugimoto. Reactivation of latent Human immunodeficiency virus 1 by Human herpesvirus 6 infection. Acta Virologica 51:13-20, (2007).

8. Y. Isegawa, M.Takemoto, K. Yamanishi, A. Ohshima, N. Sugimoto. Real-time PCR determination of human herpesvirus 6 antiviral drug susceptibility. Journal of Virological Methods 140:25-31, (2007).

9. K. Nakano, K. Tadagaki, Y. Isegawa, M. M. Aye, P. Zou, K. Yamanishi. Human herpesvirus 7 open reading frame U12 encodes a functional b chemokine receptor. Journal of Virology 77:8108-8115, (2003).

10. K. Nakano, Y. Isegawa, P. Zou, K. Tadagaki, R. Inagi, K. Yamanishi. Kaposifs sarcoma-associated herpesvirus (KSHV)-encoded vMIP-I and vMIP-II induce signal transduction and chemotaxis in monocytic cells. Archives of Virology 148:871-890, (2003).

11. M. Takemoto, T. Shimamoto, Y. Isegawa, K. Yamanishi. The R3 region, one of three major repetive regions of human herpesvirus 6, is a strong enhancer of immediate-early gene U95. Journal of Virology 75:10149-10160, (2001).

12. T. Taniguchi, T. Shimamoto, Y. Isegawa, K. Kondo, K. Yamanishi. Structure of transcripts and proteins encoded by U79-80 of human herpesvirus 6 and its subcellular localization in infected cells. Virology 271:307-320, (2000).

13. Y. Isegawa, T. Mukai, K. Nakano, M. Kagawa, J. Chen, Y. Mori, T. Sunagawa, K. Kawanishi, J. Sashihara, A. Hata, P. Zou, H. Kosuge, K. Yamanishi. Comparison of the complete DNA sequence of human herpesvirus 6 variants A and B. Journal of Virology 73:8053-8063, (1999).

14. P. Zou, Y. Isegawa, K. Nakano, M. Haque, Y. Horiguchi, K. Yamanishi. Human herpesvirus 6 open reading frame U83 encodes a functional chemokine. Journal of Virology 73:5926-5933, (1999).

15. Y. Mori, H. Yagi, T. Shimamoto, Y. Isegawa, T. Sunagawa, R. Inagi, K. Kondo, Y. Tano, K. Yamanishi. Analysis of human herpesvirus 6 U3 gene, which is a positional homolog of human cytomegalovirus UL 24 gene. Virology 249:129-139, (1998).

16. M. Kikuchi, K. Yoshimatsu, J. Arikawa, R. Yoshida, Y. C. Yoo, Y. Isegawa, K. Yamanishi, S. Tono-oka, I. Azuma. Characterization of neutralizing monoclonal antibody escape mutants of Hantaan virus 76-118. Archives of Virology 143:73-83, (1998).

17. Y. Isegawa, Z. Ping, K. Nakano, N. Sugimoto, K. Yamanishi. Human herpesvirus 6 open reading frame U12 encodes a functional ? chemokine receptor. Journal of Virology 72:6104-6112, (1998).

18. M. Ito, Y. Isegawa, H. Hotta, M. Homma. Isolation of an avirulent mutant of Sendai virus with two amino acid mutations from a highly virulent field strain through adaptation to LLC-MK2 cells. Journal of General Virology 78:3207-3215, (1997).

19. H. Kosuge, Y. Isegawa, K. Yamanishi. Nucleotide sequence analysis of a 30-kbp region of human herpesvirus-6B (HHV-6B) genome and strain-specific variation in major immediate-early genes. Virus Research 52:1-14, (1997).

20. K. Takeda, M. Haque, T. Sunagawa, T. Okuno, Y. Isegawa, K. Yamanishi. Identification of a variant B-specific neutralization epitope on glycoprotein H of human herpesvirus-6. Journal of General Virology 78:2171-2178, (1997).

21. T. Mukai, A. Hata, Y. Isegawa, K. Yamanishi. Characterization of glycoprotein H and L of human herpesvirus 7. Microbiology and Immunology 41:43-50, (1997).

22. A. Hata, T. Mukai, Y. Isegawa, K. Yamanishi. Identification and analyses of glycoprotein B of human herpesvirus 7. Virus Research 46:125-137, (1996).

23. F. Watanabe, H. Saido, R. Yamaji, K. Miyatake, Y. Isegawa, A. Ito, T. Yubisui, D. S. Rosenblatt, Y. Nakano. Mitochondrial NADH- or NADPH-linked aquacobalamin reductase activity is low in human skin fibroblasts with defects in synthesis of cobalamin coenzymes. Journal of Nutrition 126:2947-2951, (1996).

24. T. Isono, Y. Isegawa, A. Seto. Analysis of T cell receptor Vb expression in rabbit T lymphocytes induced to proliferate by an HTLV-I-transformed leukemogenic T cell line. Journal of Cancer Research Clinical Oncology 122:458-464, (1996).

25. K. Takeda, T. Okuno, Y. Isegawa, K. Yamanishi. Identification of a variant A-specific neutralizing epitope on glycoprotein B (gB) of human herpesvirus-6 (HHV-6). Virology 222:176-183, (1996).

26. H. Sagawa, A. Ohshima, I. Kato, Y. Okuno, Y. Isegawa. The immunological activity of a deletion mutant of influenza virus haemagglutinin lacking the globular region. Journal of General Virology 77:1483-1487, (1996).

27. H. Inui, O. Ohya, Y. Isegawa, S. Kitaoka, K. Miyatake, Y. Nakano. Effect of cobalamin deficiency on the biosynthesis of phosphatidylcholine in Euglena gracilis. Journal of Eukaryotic Microbiology 43:177-180, (1996).

28. R. Inagi, R. Guntapong, M. Nakao, Y. Ishino, K. Kawanishi, Y. Isegawa, K. Yamanishi. Human herpesvirus 6 induces IL-8 gene expression in human hepatoma cell line, Hep G2. Journal of Medical Virology 49:34-40, (1996).

29. K. Takeda, N. Nakagawa, T. Yamamoto, R. Inagi, K. Kawanishi, Y. Isegawa, K. Yamanishi. Prokaryotic expression of an immediate-early gene of human herpesvirus 6 and analysis of its viral antigen expression in human cells. Virus Research 41:193-200, (1996).

30. T. Mukai, Y. Isegawa, K. Yamanishi. Identification of the major capsid protein gene of human herpesvirus 7. Virus Research 37:55-62, (1995).

31. O. Nakagomi, Y. Isegawa, R. L. Ward, D. R. Knowlton, E. Kaga, T. Nakagomi, S. Ueda. Naturally occurring dual infection with human and bovine rotaviruses as suggested by the recovery of G1P8 and G1P5 rotaviruses from a single patient. Archives of Virology 137:381-388, (1994).

32. Y. Isegawa, A. Ohshima, Y. Sokawa, K. Yamanishi. Strand-specific detection of Hantaan virus RNA sequences by in vitro DNA amplification. Microbiology and Immunology 38:905-908, (1994).

33. Y. Isegawa, O. Tanishita, S. Ueda, K. Yamanishi. Association of serine in position 1124 of Hantaan virus glycoprotein with virulence in mice. Journal of General Virology 75:3273-3278, (1994).

34. S. Sato, T. Yamamoto, Y. Isegawa, K. Yamanishi. Identification of human herpesvirus-6 (HHV-6) uracil-DNA glycosylase gene. Journal of General Virology 75:2349-2354, (1994).

35. H. Kariwa, J. Arikawa, I. Takashima, Y. Isegawa, K. Yamanishi, N. Hashimoto. Enhancement of infectivity of hantavirus in cell culture by centrifugation. Journal of Virological Methods 49:235-244, (1994).

36. S. Yalcin, T. Karpuzoglu, G. Suleymanlar, G. Mutlu, T. Mukai, T. Yamamoto, Y. Isegawa, K. Yamanishi. Human herpesvirus 6 and human herpesvirus 7 infections in renal transplant recipients and healthy adults in Turkey. Archives of Virology 136:183-190, (1994).

37. H. Kariwa, Y. Isegawa, J. Arikawa, I. Takashima, S. Ueda, K. Yamanishi, N. Hashimoto. Comparison of nucleotide sequences of M genome segments among Seoul virus strains isolated from Eastern Asia. Virus Research 33:27-38, (1994).

38. T. Isono, Y. Isegawa, A. Seto. Sequence and diversity of rabbit T cell receptor beta chain variable gene segments. Immunogenetics 39:243-248, (1994).

39. N. Sakai, K. Inui, N. Fujii, I. Yanagihara, H. Fukashima, J. Nishimoto, Y. Isegawa, A. Iwamatsu, S. Okada. Krabbe disease: Isolation and characterization of full-length cDNA for human galactocerebrosidase. Biochemical and Biophysical Research Communication 198:485-491, (1994).

40. Y. Isegawa, O. Nakagomi, H. Brussow, N. Minamoto, T. Nakagomi, S. Ueda. A unique VP4 gene allele carried by an unusual bovine rotavirus strain, 993/83. Virology 198:366-369, (1994).

41. Y. Okuno, K-I. Matsumoto, Y. Isegawa, S. Ueda. Protection against mouse-adapted A/fm/1/47 strain of influenza A virus in mice by a monoclonal antibody with cross-neutralizing activity among H1 and H2 strains. Journal of Virology 68:517-520, (1994).

42. Y. Isegawa, F. Watanabe, S. Kitaoka, Y. Nakano. Subcellular distribution of cobalamin-dependent methionine synthase in Euglena gracilis Z. Phytochemistry 35:59-61, (1994).

43. O. Nakagomi, Y. Isegawa, Y. Hoshino, Y. Aboudy, I. Shif, I. Silberstein, T. Nakagomi, S. Ueda, J. Sears, J. Flores. A new serotype of the outer capsid protein VP4 shared by an unusual human rotavirus strain Ro1845 and canine rotaviruses. Journal of General Virology 74:2771-2774, (1993).

44. Y. Isegawa, M. Mochizuki, T. Nakagomi, S. Ueda, O. Nakagomi. The VP4 gene sequence of a haemagglutinating strain of feline rotavirus. Research in Virology 144:371-374, (1993).

45. O. Nakagomi, Y. Isegawa, S. Ueda, J. Flores. Two distinct clusterings of the VP8* gene of rotaviruses possessing the AU-1 gene 4 allele. Microbiology and Immunology 37:817-820, (1993).

46. O. Nakagomi, Y. Isegawa, S. Ueda, G. Gerna, A. Sarashina, E. Kaga, T. Nakagomi, J. Flores. Nucleotide sequence comparison of the VP8* gene of rotavirus possessing the AU-1 gene 4 allele. Journal of General Virology 74:1709-1713, (1993).

47. Y. Isegawa, O. Nakagomi, T. Nakagomi, S. Ishiga, S. Uesugi, S. Ueda. Determination of bovine rotavirus G and P serotypes by polymerase chain reaction. Molecular and Cellular Probes 7:277-284, (1993).

48. S. Gunasena, O. Nakagomi, Y. Isegawa, E. Kaji, T. Nakagomi, A. D. Steele, J. Flores, S. Ueda. Relative frequency of VP4 gene alleles among human rotaviruses recovered over a 10-year period (1982-1991) from Japanese children with diarrhea. Journal of Clinical Microbiology 31:2195-2197, (1993).

49. Y. Okuno, Y. Isegawa, F. Sasao, S. Ueda. A common neutralization epitope conserved between H1 and H2 hemagglutinins of influenza A virus. Journal of Virology 67:2552-2558, (1993).

50. Y. Matsuda, Y. Isegawa, G. N. Woode, E. Kaga, S. Ueda, O. Nakagomi. Two-way cross-neutralization mediated by shared P (VP4) serotype between bovine rotavirus strains with distinct G (VP7) serotype. Journal of Clinical Microbiology 31:345-358, (1993).

51. F. Watanabe, R. Yamaji, Y. Isegawa, T. Yamamoto, Y. Tamura, Y. Nakano. Characterization of aquacobalamin reducrase (NADPH) from Euglena gracilis. Archives of Biochemistry and Biophysics 305:421-427, (1993).

52. V. T. K. Chow, H. H. Quek, S. Doraisingham, A. E. Ling, Y. Isegawa. Polymerase chain reaction and direct sequencing of the inverted repeats of varicella-zoster virus DNA from Singapore. Journal of Medical Laboratory Sciences 6:67-71, (1992).

53. Y. Isegawa, J. Sheng, Y. Sokawa, K. Yamanishi, O. Nakagomi, S. Ueda. Selective amplification of cDNA sequence from total RNA by cassette-ligation mediated polymerase chain reaction (PCR): Application to sequencing 6.5 kb genome segment of hantavirus strain B-1. Molecular and Cellular Probes 6:467-475, (1992).

54. Y. Isegawa, O. Nakagomi, T. Nakagomi, S. Ueda. A VP4 sequence highly conserved in human rotavirus strain AU-1 and feline rotavirus strain FRV-1. Journal of General Virology 73:1939-1946, (1992).

55. S. Ogawa, M. P. Shrestha, S. K. Rai, M. B. Parajuli, J. N. Rai, S. C. Ghimire, K. Hirai, K. Nagata, T. Tamura, Y. Isegawa, Y. Okuno, S. Ueda. Serological and virological studies of Japanese encephalitis in the Terai region of Nepal. Southeast Asian Journal of Tropical Medicine Public Health 23:37-43, (1992).

56. Y. Isegawa, Y. Fujiwara, A. Ohshima, R. Fukunaga, H. Murakami, K. Yamanishi, Y. Sokawa. Nucleotide sequence of the M genome segment of hemorrhagic fever with renal syndrome virus strain B-1. Nucleic Acids Research 18:4936, (1990).

57. Y. Isegawa, Y. Nakano, S. Kitaoka. Photosynthesis of Euglena gracilis under cobalamin-sufficient and -limited growing conditions. Plant Physiology 84:609-612, (1987).

58. Y. Isegawa, Y. Nakano, S. Kitaoka. Conversion and distribution of cobalamin in Euglena gracilis z, with special reference to its location and probable function within chloroplasts. Plant Physiology 76:814-818, (1984).

59. Y. Isegawa, Y. Nakano, S. Kitaoka. Submitochondrial location and some properties of NAD+ and NADP+-linked malate dehydrogenase in Euglena. Agricultural and Biological Chemistry 48:549-552, (1984).